Fifteen people were taken to hospital following a head-on collision between two four-wheel-drives near Lismore on Saturday afternoon.

The Mitsubishi Pajero and Toyota Landcruiser collided in heavy rain on Whyralla Road, Buckendoon, shortly after midday.

Fifteen people were treated at Lismore Base Hospital for various injuries – three of them in serious condition.

One of them, a nine-year-old girl, was later airlifted from Lismore to Royal Brisbane Hospital suffering a suspected fractured spine.

Police from Richmond Local Area Command and the Ballina Crash Investigation Unit are continuing their inquiries into the cause of the collision.