A man and a woman have died in separate crashes at Drake and near Bangalow today.

At 8:25am, a Toyota Tarago van was travelling east on the Bruxner Highway at Drake when the van rounded a bend, veered off the road and rolled several times.

As a result of the crash, a man died at the scene, while five other people were injured and taken to Lismore Base Hospital suffering varying injuries including a severed finger, neck and chest injuries and one suffering spinal injuries.

Emergency services remained on scene on Saturday afternoon, with one lane west-bound open to allow traffic through a contra-flow system.

About 11:10am, three vehicles collided on the Pacific Highway near Bangalow, resulting in the death of a woman.

It is believed a Toyota Camry station wagon was travelling south on the highway when it crossed onto the opposite side of the road and collided with a car towing a caravan, and a Kia Carnival van.

As a result of the crash, the female driver and sole occupant of the Camry died at the scene.

Four people were taken by ambulance to Tweed Heads Hospital, another two to Byron Bay Hospital and one flown by the Lifesaver Helicopter to Lismore Base Hospital.

Officers from the Ballina Crash Investigation Unit attended, and all northbound lanes were being diverted onto Coolamon Scenic Drive, while heavy vehicles were urged to avoid the area.

Earlier today, two people died when a Holden Commodore sedan and a B-double truck collided at the intersection of the New England Highway and Grafton Street, Glen Innes.